Cytokine receptor - Wikipedia
Cytokine receptors are receptors that bind to cytokines. [ 1 ] In recent years, the cytokine receptors have come to demand the attention of more investigators than cytokines themselves, partly because of their remarkable characteristics, and partly because a deficiency of cytokine receptors has now been directly linked to certain debilitating ...
Dictionary of immune responses to cytokines at single-cell
Dec 6, 2023 · We created cytokine response and cytokine–receptor expression maps and used them to derive a cell–cell interactome that illustrated diverse ways that immune cells can interact with one...
Cytokines, Chemokines and Their Receptors - Madame Curie …
The proceeding sections will introduce many of the currently identified cytokines and chemokines, along with their receptors. You will find that cytokines and chemokines with related structure and/or function are clustered into groups of interdependent homologues, e.g., the …
Cytokine Receptors - SpringerLink
Jan 26, 2018 · Cytokine receptors initiate intracellular signaling that regulate a diverse range of biological and medically important functions including metabolism control, neural stem cell activation, inflammatory responses, bone development, as well as blood cell and immune cell development and growth.
Cytokines: From Clinical Significance to Quantification - PMC
Consequently, cytokine receptors prevent cytokines from binding their specific membrane receptors and generating a signal, leading to inhibition of cytokines activity. [107] The antagonistic effects of soluble cytokine receptors may play an important role in the down‐regulation of immune responses and in the inhibition of “overactivity ...
Cytokines: Introduction | British Society for Immunology
Receptor engagement triggers intracellular signalling cascades leading to altered gene expression in the target cell, which lead to a biological effect (Figure 1). Differentiation, proliferation and activation of the target cell are all effects which can be detected after cytokine stimulation.
Cytokine Receptor - an overview | ScienceDirect Topics
Cytokine Receptors are a type of receptor that do not have their own tyrosine kinase activity, but instead associate with a cytosolic kinase when they bind to their specific ligands, which are cytokines.
Cytokines in the balance - Nature Immunology
Nov 19, 2019 · The understanding of cytokine signaling has expanded to recognize synergistic cross-talk pathways that allow dynamic tissue-specific and context-dependent immune responses. However, with that ...
Emerging principles of cytokine pharmacology and therapeutics
Sep 21, 2022 · Cytokines are secreted growth factors that initiate signalling on target cells by engaging the extracellular domains (ECDs) of cell surface receptors to compel receptor dimerization, in a...
Cytokine Receptor - an overview | ScienceDirect Topics
Cytokine receptors possess a conserved extracellular region (cytokine receptor homology domain [CDH]) and several structural modules, including extracellular immunoglobulin or fibronectin type III–like domains, transmembrane domains, and intracellular homology regions.