Prophecy" chapter ended with Desmond Hart squaring off against Mother Superior Valya Harkonnen and deflecting her homicidal use of The Voice to get him to kill himself, and Sister Lila now lost in a coma after experiencing the horrors of genetic memory while enduring The Agony.

Dune: Prophecy takes a deep dive into the lives of Valya and Tula Harkonnen, ending with a sequence where Valya visits her uncle and nephew. Actors Emily Watson and Jessica Barden play Valya Harkonnen,

Sisterhood above all” is the motto of Valya and Tula’s secretive organization, but its meaning seems to depend on which sister is saying it.