eLife2d
Kidney Fibrosis: Lock out SIRT4
The accumulation of SIRT4 in the nuclei of kidney cells drives kidney fibrosis, so blocking the movement of this protein could be a potential therapeutic strategy against fibrosis.
eLife2d
Passive shaping of intra- and intercellular m6A dynamics via mRNA metabolism
m6A is the most widespread mRNA modification and is primarily implicated in controlling mRNA stability. Fundamental questions pertaining to m6A are the extent to which it is dynamically modulated ...
eLife2d
Inclusive, Exclusive and Hierarchical Atlas of NFATc1 + /PDGFR-α + Cells in Dental and Periodontal Mesenchyme
State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, China Department of Endodontics, West China ...
eLife2d
Limited column formation in the embryonic growth plate implies divergent growth mechanisms during pre- and postnatal bone development
Chondrocyte columns, which are a hallmark of growth plate architecture, play a central role in bone elongation. Columns are formed by clonal expansion following rotation of the division plane, ...
eLife2d
A General Mechanism for the General Stress Response in Bacteria
Department of Biochemistry, Brandeis University, Waltham, Massachusetts, USA Graduate program in Biochemistry and Biophysics, Brandeis University, Waltham, Massachusetts, USA Biophysics Collaborative ...
eLife2d
Robust variability of grid cell properties within individual grid modules enhances encoding of local space
Interdepartmental Graduate Program in Dynamical Neuroscience, University of California, Santa Barbara Although grid cells are one of the most well studied functional classes of neurons in the ...
eLife2d
Single dopaminergic neuron DAN-c1 in Drosophila larval brain mediates aversive olfactory learning through D2-like receptors
The intricate relationship between the dopaminergic system and olfactory associative learning in Drosophila has been an intense scientific inquiry. Leveraging the formidable genetic tools, we ...
eLife2d
Simply crushed Zizyphi spinosi semen prevents neurodegenerative diseases and reverses age-related cognitive decline in mice
Department of Translational Neuroscience, Osaka Metropolitan University Graduate School of Medicine, 1-4-3 Asahimachi, Abeno-ku, Osaka 545-8585, Japan Cerebro Pharma Inc., 4-5-6-3F Minamikyuhojimachi, ...
eLife3d
Improved inference of population histories by integrating genomic and epigenomic data
The developed statistical method paves the way for next generation demographic and selection inference by combining information from several heritable genomic and epigenomic markers.
eLife3d
CUTS RNA Biosensor for the Real-Time Detection of TDP-43 Loss-of-Function
CUTS is a cryptic exon RNA biosensor enabling real-time detection of TDP-43 loss of splicing function. CUTS exhibits a significant linear relationship with TDP-43 loss. CUTS can deliver an ...
eLife3d
Multi-tissue network analysis reveals the effect of JNK inhibition on dietary sucrose-induced metabolic dysfunction in rats
The authors present a valuable study exploring the interaction between JNK signaling and high sucrose feeding. The strength of evidence supporting these observations is solid, including multi-tissue ...
eLife3d
Regulation of lung cancer initiation and progression by the stem cell determinant Musashi
Despite advances in therapeutic approaches, lung cancer remains the leading cause of cancer-related deaths. To understand the molecular programs underlying lung cancer initiation and maintenance, we ...