BMJ1d
PPARγ preservation via promoter demethylation alleviates osteoarthritis in mice
Objectives Osteoarthritis (OA) is the most common degenerative joint disease in aged population and its development is significantly influenced by aberrant epigenetic modifications of numerous OA ...
BMJ2d
Vascularised human skin equivalents as a novel in vitro model of skin fibrosis and platform for testing of antifibrotic drugs
Correspondence to Dr Jörg H W Distler, Department of Internal Medicine 3 – Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, ...
BMJ4d
Synovial fibroblasts assume distinct functional identities and secrete R-spondin 2 in osteoarthritis
Correspondence to Dr Tristan Maerz, Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, Michigan, USA; tmaerz{at}med.umich.edu Objectives Synovium is acutely affected following joint ...
BMJ4d
Synovial macrophage M1 polarisation exacerbates experimental osteoarthritis partially through R-spondin-2
Correspondence to Professor Daozhang Cai and Dr Xiaochun Bai, Department of Orthopedics, Academy of Orthopedics - Guangdong Province, Orthopedic Hospital of Guangdong Province, The Third Affiliated ...
BMJ2d
Antiphospholipid antibodies, systemic lupus erythematosus, and non-traumatic metatarsal fractures
The Lupus Research Unit, The Rayne Institute, Lambeth Wing, St Thomas’ Hospital, London, UK Correspondence to: Dr D P D’Cruz The Lupus Research Unit, The Rayne Institute, St Thomas’ Hospital, London ...
BMJ2d
Humanised effector-null FcγRIIA antibody inhibits immune complex-mediated proinflammatory responses
Objective Immune complexes (ICs) play a critical role in the pathology of autoimmune diseases. The aim of this study was to generate and characterise a first-in-class anti-FcγRIIA antibody (Ab) ...
BMJ4d
Risk of serious infections in tocilizumab versus other biologic drugs in patients with rheumatoid arthritis: a multidatabase cohort study
Objective To investigate the rate of serious bacterial, viral or opportunistic infection in patients with rheumatoid arthritis (RA) starting tocilizumab (TCZ) versus tumour necrosis factor inhibitors ...
BMJ6d
Phagocytosis and antigen presentation: a partnership initiated by Toll-like receptors
Professional phagocytes play an important role in the clearance of microbial pathogens and apoptotic cells. Many receptors are involved in this process, some with signalling capabilities, some without ...
BMJ4d
Vitamin D receptors in the rheumatoid lesion: expression by chondrocytes, macrophages, and synoviocytes
University Department of Medicine, Manchester Royal Infirmary, Oxford Road, Manchester, M13 9WL Dr D E Woolley. METHODS Immunolocalisation techniques using a rat monoclonal antibody to VDR and an ...
BMJ4d
Taxonomy of fibroblasts and progenitors in the synovial joint at single-cell resolution
Objectives Fibroblasts in synovium include fibroblast-like synoviocytes (FLS) in the lining and Thy1+ connective-tissue fibroblasts in the sublining. We aimed to investigate their developmental origin ...
BMJ4d
How to cope with pathogenic long-lived plasma cells in autoimmune diseases
Deutsches Rheumaforschungszentrum Berlin and Department of Rheumatology, Charité, Universitätsmedizin Berlin, Berlin, Germany Dr B F Hoyer, Deutsches Rheumaforschungszentrum Berlin and Department of ...
BMJ4d
POS0894 ANTI-IL-6 THERAPY EFFECT FOR REFRACTORY JOINT AND SKIN INVOLVEMENT IN SYSTEMIC SCLEROSIS: A REAL-WORLD, SINGLE CENTER EXPERIENCE
Background: Emerging evidence during the last two decades supports a pivotal role of Interleukin 6 (IL-6) in the pathogenesis of Systemic Sclerosis (SSc). Standard immunosuppressive agents are often ...