McCaffrey was the Offensive Player of the Year last season after leading the NFL with 339 touches, 1,459 rushing yards, 2,023 scrimmage yards and 21 touchdowns. His return will give the 49ers’ offense a boost after they struggled to score touchdowns without him in the first eight weeks.

The 49ers are coming off their bye and kicking off the second half of their season at the Buccaneers on Sunday. Don't let their slow start fool you. Even at 4-4, the 49ers still have the second-best Super Bowl odds in the NFC behind the Lions.