After a 23-17 upset loss to the Minnesota Vikings in Week 2, the 49ers are 1-1 on the year and are officially vulnerable to opposing NFL teams while they cope with injuries. They have the winless Los Angeles Rams on tap in Week 3, giving them the first opportunity to show their resilience as a team without their two best playmakers.

It’s not just the Los Angeles Rams who will be missing two of their best offensive players on Sunday. The San Francisco 49ers will, too. Already without Christian McCaffrey, who’s on injured reserve,

The San Francisco 49ers will be without the services of one of their top offensive weapons for the foreseeable future.

The injuries are starting to pile up for the 49ers’ offense. San Francisco head coach Kyle Shanahan told reporters on Monday that star wide receiver Deebo Samuel will miss “a couple” of weeks with a calf strain sustained in Sunday’s loss to the Vikings.