Tumor-infiltrating lymphocytes and other T cell-mediated treatments, such as CAR-T, have the potential to improve the effectiveness and personalization of cancer care. Cytokines play a crucial ...

Macrophages interact with T cells in order to bring about T cell activation in target organs, and are themselves activated by inflammatory messenger molecules (cytokines) produced by the T cells.

Cytokines IL-6, IL-27, IL-21, and TGF-β1 partner with IL-23 and IL-12 to initiate the differentiation of naive T cells. Consequently, there is an increase in Bcl-6 and upregulation of ICOS ...

Interleukins are cytokines produced and secreted mainly by CD3+ and CD4+ T lymphocytes. Interleukins promote development and differentiation of natural killer cells, T and B lymphocytes and ...

They found that in the presence of Parkin, interferons—a group of cytokine proteins that aid in immune responses to ...

Working with UChicago's Cellular Screening Center, Knight screened 2,000 small molecules on live cells and tested the level ...

Rapamycin is used to prevent graft rejection in transplant recipients based on its ability to suppress T-cell proliferation. The drug blocks the activity of a protein known as mammalian target of ...

[6] Initiation refers to early paracrine-mediated changes in gene expression and phenotype that render the cells responsive to other cytokines ... Locally produced vasodilator substances may ...

Pro-inflammatory cytokines (TNF-α, IL-6, and IL-1β) are produced in large ... from ApoB by antigen-presenting cells (APCs) promotes the formation of effector T cells from naïve (CD4 +) T ...

Sickness-induced sleep is a behavior conserved across species that promotes recovery from illness, yet the underlying mechanisms are poorly understood. Here, we show that interleukin-6-like cytokine ...

To address the unmet need for a cure for RTT, the therapeutic potential of adult Neural Precursor Cells (NPCs) was ...

The gastrointestinal microbiome remains an explosively increasing topic of study, assessing the potentially pivotal roles of the microbiome in maintaining health or causality in disease pathogenesis.