The San Francisco 49ers officially have a significant injury problem on their hands. Running back Christian McCaffrey is out ...

San Francisco 49ers wide receiver Brandon Aiyuk will be the first guest to appear on his teammates' show Cleats and Convos ...

The San Francisco 49ers offense got a bit thinner when one of their top wideouts suffered a calf strain in their Week 2 loss ...

The San Francisco 49ers are dealing with some devastating early-season injuries to Deebo Samuel and Christian McCaffrey. It's ...

Kyle Shanahan and the San Francisco 49ers believe there were wasted opportunities for Brandon Aiyuk in the loss to the ...

The San Francisco 49ers offense was dealt another blow with star receiver Deebo Samuel getting sidelined by a strained calf.

The San Francisco 49ers can’t catch a break on the injury front. Head coach Kyle Shanahan didn’t have any updates in his ...

San Francisco 49ers star wide receiver Deebo Samuel will miss a few weeks with a calf strain, head coach Kyle Shanahan told ...

Deebo Samuel, the pass-catching and ground game extraordinaire whose versatility has shined over the past few seasons, is ...

The San Francisco 49ers "checked in" with the Minnesota Vikings about a possible trade for wide receiver Justin Jefferson in ...

Amid the offseason uncertainty surrounding Brandon Aiyuk, the 49ers checked in on Justin Jefferson's availability before this ...

After Sunday, however, the Bay Area knows Darnold much better, and 49ers faithful probably wish they didn't. Making his home ...