eLife3d
CUTS RNA Biosensor for the Real-Time Detection of TDP-43 Loss-of-Function
CUTS is a cryptic exon RNA biosensor enabling real-time detection of TDP-43 loss of splicing function. CUTS exhibits a significant linear relationship with TDP-43 loss. CUTS can deliver an ...
eLife2d
Robust variability of grid cell properties within individual grid modules enhances encoding of local space
Interdepartmental Graduate Program in Dynamical Neuroscience, University of California, Santa Barbara Although grid cells are one of the most well studied functional classes of neurons in the ...
eLife2d
Limited column formation in the embryonic growth plate implies divergent growth mechanisms during pre- and postnatal bone development
Chondrocyte columns, which are a hallmark of growth plate architecture, play a central role in bone elongation. Columns are formed by clonal expansion following rotation of the division plane, ...
eLife5d
The effects of 17α-estradiol treatment on endocrine system revealed by single-nucleus transcriptomic sequencing of hypothalamus
Together, the findings suggested that 17α-estradiol extensively reshaped the cell populations, cellular communication, neuropeptide secretion, and neural synapse activity in aged hypothalamus, which ...
eLife2d
Kidney Fibrosis: Lock out SIRT4
The accumulation of SIRT4 in the nuclei of kidney cells drives kidney fibrosis, so blocking the movement of this protein could be a potential therapeutic strategy against fibrosis.
eLife11d
eLife Global South Committee for Open Science: Applications open for candidates to join for a two-year term
One year after forming this Committee, we’re inviting applications from researchers in the Global South to join for a term ...
eLife4d
Distinguishing mutants that resist drugs via different mechanisms by examining fitness tradeoffs
Nearly a thousand diverse adaptive mutants converge into a handful of groups for which fitness responds the same way to ...
eLife5d
Individuals with anxiety and depression use atypical decision strategies in an uncertain world
A model with a mixture of three different decision strategies is developed to characterize several atypical behavioral patterns of individuals with depression and anxiety in an uncertain reward ...
Opinion
eLife5dOpinion
Point of View: Applied research won’t flourish without basic science
Three senior figures at the US National Institutes of Health explain why the agency remains committed to supporting basic science and research.
eLife3d
Regulation of lung cancer initiation and progression by the stem cell determinant Musashi
Despite advances in therapeutic approaches, lung cancer remains the leading cause of cancer-related deaths. To understand the molecular programs underlying lung cancer initiation and maintenance, we ...
eLife3d
Improved inference of population histories by integrating genomic and epigenomic data
The developed statistical method paves the way for next generation demographic and selection inference by combining information from several heritable genomic and epigenomic markers.
eLife6d
BCAS2 promotes primitive hematopoiesis by sequestering β-catenin within the nucleus
However, whether BCAS2 has other functions within the nucleus remains largely unknown. Here, we show that BCAS2 is essential for primitive hematopoiesis in zebrafish and mouse embryos. The activation ...