The San Francisco 49ers have placed All-Pro running back Christian McCaffrey on injured reserve because of his lingering calf ...

A San Francisco 49ers star defender did not mince his words when talking about the New York Jets after their Week 1 matchup.

Christian McCaffrey will miss at least the 49ers’ first five games this season as they put him on the injured reserve list ...

A disaster scenario has hit fantasy football managers who spent an early first-round pick on San Francisco 49ers star ...

Rookie right guard Dominick Puni has earned the respect of San Francisco 49ers star left tackle Trent Williams along the ...

A pair of outstanding runners will be on display when Jordan Mason and the San Francisco 49ers visit Aaron Jones and the ...

Do we have a revenge game on our hands in NFL Week 2? Sam Darnold – the San Francisco 49ers backup quarterback last season – ...

Suddenly the 49ers have just one healthy running back they trust. Christian McCaffrey has Achilles tendonitis and could go to ...

Here are the latest predictions, picks, and odds for the 2024 NFL Week 2 matchup between the San Francisco 49ers and the ...

Analyzing Sunday’s San Francisco 49ers at Minnesota Vikings odds and lines, with expert NFL picks and predictions.

Both the Vikings and 49ers dominated their Week 1 opponents. Only one can leave Week 2 still undefeated, and only limited ...

The 49ers and Vikings had two of the Top 5 most impressive wins during Week 1 of the NFL season, but only one can come away 2 ...