Low event rates and short TTRs with warfarin were notable, and questions persist as to which patients truly need OAC.

Although there are no documented reports of feverfew interacting with warfarin in humans, pharmacologic data suggest the potential for additive anticoagulant effects in the presence of warfarin.

In patients with protein C and protein S deficiency, when warfarin therapy is started there is a more rapid fall in concentration of protein C (antigen and activity) than the other vitamin K ...

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