Activation of macrophage TLR4 by bacterial endotoxins is important for the progression of sepsis, but the underlying ...

RPE-1 cells adapt to aneuploidy in vitro, a process characterized by reduced CIN and inflammation. This study shows that this ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and ...

MDA5 is a critical cytoplasmic RNA sensor capable of triggering type I interferon pathways. This study shows that the E3 ...

How the hydrolytic activity of mitochondrial ATP synthase is modulated during brown adipose tissue (BAT) thermogenesis ...

A machine-learning method predicts whether a genetic variant is pathogenic and affects certain human tissues. The ...

K Heran Darwin is at New York University Grossman School of Medicine and a regular columnist for EMBO reports.

Metabolic rewiring is essential for osteoclast differentiation and bone resorption. This study shows that glutaminolysis ...

Changing nutrient environments challenge cells as they affect both protein biosynthesis and cell cycle length. This work ...

Human papillomavirus (HPV) and hyperactivated YAP1 form a YAP1-HPV oncogenic alliance to drive the malignant transformation ...

It is boomtime for metabolism and metabolomics research. One hundred years after Otto Warburg put metabolism at the core of ...

FAO is catalyzed by the mitochondrial trifunctional protein (MTP) and, if overloaded, generates ROS. ROS are boosted during ...