The 49ers just lost their second game in a row by at least 25 points for the first time since Jim Tomsula was the head coach.

The Buffalo Bills didn't just beat the San Francisco 49ers on Sunday night. They destroyed the reigning NFC champions. The ...

The Buffalo Bills dominated the San Francisco 49ers on Sunday Night Football, rumbling past them 35-10. Not only did this win ...

The Buffalo Bills hammered the San Francisco 49ers 35-10 in a snow-filled rout led by Josh Allen’s 4 TDs. Colin Cowherd ...

On a snowy night in Orchard Park, N.Y., the Buffalo Bills clinched the AFC East title with a dominant win over the San ...

Buffalo Bills wide receiver Mack Hollins arrived at Highmark Stadium barefoot despite the 31-degree temperature, here's why ...

President-elect Donald Trump has pledged to shake things up in Washington in his second term. Here are the two main changes ...

Following a brutal 38-10 loss to the Green Bay Packers last week, things didn't get any easier for the San Francisco 49ers ...

Quarterback Josh Allen and coach Sean McDermott deserve credit in overcoming lowered expectations in leading the Buffalo ...

The Buffalo Bills are used to hosting high-stakes games in the snow. So, it might not be a surprise that they easily defeated ...

NFL Week 14 odds, picks, predictions, TV channel, streaming information for the Sunday football game between the Buffalo ...

The Bills and 49ers play Sunday, Dec. 1 at 8:20 p.m. at Highmark Stadium in Orchard Park. The game will be broadcast on local ...