While the 49ers look like an easy opponent, San Francisco's health could be a major factor in the game, warns one NFL expert. If they get back the right players, the Bills will be facing a much tougher game against a playoff-level team desperate to keep their hopes alive.

The first-place Buffalo Bills are on a six-game winning streak and getting healthier. The last-place San Francisco 49ers have dropped two straight games and are beleaguered by injuries. Buffalo has Super Bowl aspirations and San Francisco played in the ...

The Buffalo Bills are fresh off of their bye week heading into a Sunday Night Football matchup with the San Francisco 49ers, who are in serious danger of missin

The 49ers travel to Buffalo to take on the AFC East-leading Buffalo Bills. Check out our best bet for the game

NFL Week 13 odds, picks, predictions, TV and streaming information for Sunday Night Football game between the San Francisco 49ers and Buffalo Bills.

San Francisco has put up a combined 27 points the past two weeks and faces a Bills defense great at generating pressure with just the front four. Buffalo is Top 10 in EPA allowed per pay and very stingy against the run, sitting seventh in run-stop win rate at ESPN and No. 9 in opponent success rate per handoff.