Cytokine Regulation and Function in T Cells - PubMed
WEBApr 26, 2021 · T lymphocytes, the major effector cells in cellular immunity, produce cytokines in immune responses to mediate inflammation and regulate other types of immune cells. Work in the last three decades has revealed significant heterogeneity in CD4 + T cells, in terms of their cytokine expressio …
The adaptive cellular immune response: T cells and cytokines
WEBJan 30, 2023 · T cells regulate the activities cells participating in immune responses. They provide help for antibody production by B cells, and they are also the effectors of antigen-specific cell-mediated immunity (CMI).
Cytokine Regulation and Function in T Cells | Annual Reviews
WEBMechanisms exist to prevent cytokine production by T cells to maintain immune tolerance to self-antigens, some of which may also underscore immune exhaustion in the context of tumors. Understanding cytokine regulation and function has offered innovative treatment of many human diseases.
Cytokines: From Clinical Significance to Quantification
WEBJun 10, 2021 · Based on their cellular source, cytokines are classified into type 1 cytokines, produced by cluster of differentiation 4 (CD4)+ T‐helper 1 (T h 1) cells, including IL‐2, IL‐12, IFN‐γ, and TNF‐β; and type 2 cytokines, produced by CD4+ T h 2 cells, including IL‐4, IL‐5, IL‐6, IL‐10, and IL‐13.
T cell subsets and their signature cytokines in autoimmune and ...
WEBOct 14, 2016 · T helper cell subset differentiation and the protective and pathogenic roles of their lineage-signature cytokines. The signature cytokines for each subset are shown in bold.
T cell subsets and their signature cytokines in autoimmune and ...
WEBThis article reviews the different Th subsets in terms of cytokine profiles, how these cytokines influence and shape the immune response, and their relative roles in promoting pathology in autoimmune and inflammatory diseases.
T cells in health and disease | Signal Transduction and ... - Nature
WEBJun 19, 2023 · In this review, we summarize the current understanding of T cell development, CD4+ and CD8+ T cell classification, and differentiation in physiological settings.
T cell receptor and cytokine signal integration in CD8 - Nature
WEBJan 13, 2020 · Signals from low-affinity pMHC and cytokines synergistically induce phosphorylation of the kinase Akt, metabolic changes and c-Myc transcription factor induction in CD8 + T cells only in the...
Cytokines: From Clinical Significance to Quantification
WEBCytokines are soluble proteins with low molecular weight (≈6–70 kDa), secreted from a variety of cells (lymphocytes, macrophages, natural killer (NK) cells, mast cells, and stromal cells).
CD8 T-cell subsets: heterogeneity, functions, and therapeutic …
WEBNov 1, 2023 · Traditionally, cytotoxic T cells, characterized by their ability to produce effector cytokines and release cytotoxic granules to directly kill target cells, have been recognized as the...
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