Prostate-specific antigen - Wikipedia
WEBProstate-specific antigen (PSA), also known as gamma-seminoprotein or kallikrein-3 (KLK3), P-30 antigen, is a glycoprotein enzyme encoded in humans by the KLK3 gene. PSA is a member of the kallikrein -related peptidase family and is secreted by the epithelial cells of the prostate gland in men and the paraurethral glands in women. [5]
Prostate-specific membrane antigen (PSMA)–ligand positron …
WEBMar 9, 2020 · Molecular structure of prostate-specific membrane antigen (PSMA). Prostate-specific membrane antigen (PSMA) monomer has three domains. J591 antibody binds to activity site of extracellular domain which has 707 amino acids. 7E11 antibody binds to intracellular domain which has 19 amino acids.
Dr. Eric Klein discusses the novel IsoPSA test for prostate cancer
WEBJan 20, 2022 · And they measure the amount of the major PSA molecules in the bloodstream. IsoPSA takes us back to eighth grade aqueous chemistry class. It measures the PSA related proteins that are present in blood in a way that looks at their chemical structure rather than their concentration.
Twenty Years of PSA: From Prostate Antigen to Tumor Marker
WEBIn 1987, molecular sieve methods unexpectedly found 2 forms of PSA in the sera of patients with prostate cancer: a small (36 kDa) and a large (90–100 kDa) molecular form. The expected molecular size of PSA from biochemical characterization of tissue PSA by amino acid sequencing is about 26 kDa.
Prostate-Specific Antigen Testing: Overview, Physiologic ...
WEBJun 1, 2023 · Prostate-specific antigen (PSA) is a protein produced by normal prostate cells. This enzyme participates in the dissolution of the seminal fluid coagulum and plays an important role in...
Characterisation of the main PSA glycoforms in aggressive prostate ...
WEBNov 4, 2020 · The results showed that blood serum PSA sialylated glycoforms containing GalNAc residues were largely increased in aggressive PCa patients, whereas the disialylated core fucosylated biantennary...
Molecular Form Differences Between Prostate-Specific Antigen (PSA ...
WEBFeb 25, 2016 · PSA, independently discovered by several researchers 2 and in 1979 purified from prostatic tissue 3, is an N-linked glycoprotein 4 comprised of a 237 amino acid residue (28,400 Daltons (Da)).
Carbohydrate structure and differential binding of prostate …
WEBMar 24, 2004 · The predominant core structure of N-glycans of seminal fluid PSA was a complex type biantennary oligosaccharide and was consistent with the structure reported previously. However, we found the sialic acid α2-3 galactose linkage as an additional terminal carbohydrate structure on seminal fluid PSA.
Analysis of Free Prostate-specific Antigen (PSA) after Chemical …
WEBApr 1, 2000 · The chemical method described here allows the cleavage of the PSA-ACT complex in human blood and the isolation of the liberated PSA, making it amenable for structural investigations.
WEBThe ductal epithe-lium is responsible for production and secretion of prostate speci®c antigen (PSA). The basement membrane creates a barrier preventing escape of PSA into the peripheral circulation.
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